A simple man, Dr. Walter Newman has high aspirations to cure all disease through genetic manipulation. His obsession with his mission draws him deeper into his own dark world, distracting him from his wife Olivia and from his responsibilities to his patients at the Edgewood Asylum. The doctor’s loyal but diabolical nurse, Ms. Tinsley, decides to take matters into her own hands and in secret she conducts her own experiment. When Dr. Newman realizes what has been done, a deformed creature that defies nature is created. Part human, part nightmare. Dr. Newman knows what he must do, but is it already too late?

A young boy fighting cancer writes letters to God, touching lives in his neighborhood and inspiring hope among everyone he comes in contact. An unsuspecting substitute postman, with a troubled life of his own, becomes entangled in the boy’s journey and his family by reading the letters. They inspire him to seek a better life for himself and his own son he’s lost through his alcohol addiction.