After falling off the roof at a New Year’s Eve house party, Owen decides that it’s time to make some wholesale changes in his life. Over the next year, he quits drinking, re-enters his estranged son’s life, reignites old friendships, and falls in love with Vera, a bank teller and fellow divorcee…all in an attempt to replace members of his family who he’d lost prematurely.

On a remote former submarine refueling facility called Aquatica, a team of scientists are searching for a cure for Alzheimer’s disease. Dr. Susan McAlester genetically engineers three Mako sharks, intending to increase their brain capacity so that they can harvest the tissue as a cure for Alzheimer’s. Unfortunately, the increased brain capacity also makes the sharks smarter, faster, and more dangerous. Aquatica’s financial backers are skeptical and nervous about the tests, and send a corporate executive to visit the facility.