In an isolated rural community of Quebec, Canada, some inhabitants attack other people, hungry for human flesh. A few survivors gather and go deep into the forest to escape them.

Francis is a young gay man, Marie is a young straight woman and the two of them are best friends — until the day the gorgeous Nicolas walks into a Montreal coffee shop. The two friends, instantly and equally infatuated, compete for Nicolas’ indeterminate affections, a conflict that climaxes when the trio visit the vacation home of Nicolas’ mother. The frothy comedy unfolds through narrative, fantasy sequences and confessional monologues.

It all starts at daybreak, three young surfers on the raging seas. A few hours later, on the way home, an accident occurs. Now entirely hooked up to life-support in a hospital in Le Havre, Simon’s existence is little more than an illusion. Meanwhile, in Paris, a woman awaits the organ transplant that will give her a new lease on life.

Twelve-year-old Simone feels painfully disconnected from the world after witnessing the brutal death of her mother. Simone, a solitary multimedia artist in her twenties, is struggling to control her crushing panic attacks and keep her day job in an underground parking lot. And Simone, a sixty-year-old physicist, is giving a conference on the nature of time. The three Simones’ lives are intertwined in a labyrinthine meta-world where timeframes overlap, characters multiply, and storylines repeat and expand. But, for all its shuttling forward and back through time, ENDORPHINE remains grounded in the Simones’ inner lives — it’s an artistic examination of scientific phenomena that also poignantly explores how people deal with trauma.