Cannibal Taboo tells the story of Janet, a young woman raised in the wilds of Africa who is rescued by explorer Cliff Hendricks. When Cliff contracts a rare blood disease, Janet must leave her jungle ways to care for her husband and their four children. The bulk of the plot occurs when the youngest son, Paul, is about to have his twenty-first birthday. His brother Luke, a successful professor, returns for the celebration. However, things are not so simple in the Hendricks household, since fourth sibling Matthew disappeared on his twenty-first. Moreover, Paul and his sister have an incestuous relationship, and Janet is harboring a terrible secret.

Mike and Toni are on their way to the mountains for a romantic weekend, when their car breaks down. The couple take shelter in an empty cabin, unaware that it is being used by bisexual photographer Jan who is on an erotic shoot with model Kristin. Things get more complicated when Glen, a fashion editor, arrives. Soon inhibitions (and underwear) are being freely cast aside. But the lovers’ reverie is broken when Kristin’s psychotic boyfriend breaks in, seeking vengeance.