Dr. Vasi invents a super-powered robot, Chitti, in his own image. The scientific body, AIRD, that must approve the robot, declines it based on its not having emotions and the ability to make rational judgment. A sudden flash of lightning evokes emotions in the robot, and Chitti is seemingly ready for integration into the human world. Then, Chitti falls in love with Dr. Vasi’s fiancée Sana and turns on his creator.

A few individuals in the medical profession are murdered or kidnapped, and the cop investigating the case suspects a doctor and arrests him. But is he the one who is behind these crimes? And why are they being committed?