Dirty Harry Callahan returns again, this time saddled with a rookie female partner. Together, they must stop a terrorist group consisting of angry Vietnam veterans.

Robert Neville, a doctor, due to an experimental vaccine, is the only survivor of an apocalyptic war waged with biological weapons. The plague caused by the war has killed everyone else except for a few hundred deformed, nocturnal people calling themselves “The Family”. The plague has caused them to become sensitive to light, as well as homicidally psychotic.