Jack Ford leads a special forces unit back to the United States to hunt down Jake Gabriel, a soldier who has been infected with the werewolf virus that turns man into wolf. Little does Jack know that three of the female soldiers serving in his unit have also been infected and have already transformed into she-wolves. The she-wolves’ forces of evil and Ford’s special op forces of good, are pitted against each other in the race to save mankind from turning into wolves.

Five young New Yorkers throw their friend a going-away party the night that a monster the size of a skyscraper descends upon the city. Told from the point of view of their video camera, the film is a document of their attempt to survive the most surreal, horrifying event of their lives.