Things spiral out of control in a high school in Manhattan when a terrible accident involving a science experiment injures a kid for life.

A circle of thirty-something friends reunite for a weekend away to celebrate the same sex wedding of a member of their group. Yet, despite their best efforts to behave themselves, a series of surprise plans, unexpected arrivals and exposed secrets lead to an explosion of drama that, coupled with the flammable combination of hurt feelings, unresolved tensions, and lots of wine cannot be contained.

Two free-spirited stoners find themselves catapulted into 2016 after smoking some top secret pot created by the CIA in 1986. With 30 years of their lives lost, these now balding and overweight friends use their uncomplicated enthusiasm to get their lives back on track and figure out the modern world.