Robert Neville, a doctor, due to an experimental vaccine, is the only survivor of an apocalyptic war waged with biological weapons. The plague caused by the war has killed everyone else except for a few hundred deformed, nocturnal people calling themselves “The Family”. The plague has caused them to become sensitive to light, as well as homicidally psychotic.

In WW2, a RAF squadron leader mourns the death of a comrade and receives a bombing mission against a secret Nazi V-2 rocket testing facility in France.